Tracking down High Security Lockbox locations is only the first step in cracking open these rare treasure chests in The Outer Worlds 2. Each one contains a special unique weapon or piece of armor that usually has a pretty strong skill, though to actually open them you'll first have to find enough Advanced Decryption Keys.
The rarity of said keys makes choosing which lockboxes to open a tough decision. Though, as you explore Arcadia's many moons and planets, you'll find more High Security Lockboxes with a wider variety of unique gear, so there's nothing wrong with holding onto your keys until you find something you actually want.
