A 25-year-old woman checked into a Phase I clinical trial ward in Shanghai, swallowed a 20-milligram tablet, and began producing urine that glowed a vivid fluorescent yellow. Not under a black light. Under ordinary room lighting, in a graduated cylinder and in the collection barrel, bright enough to see with the naked eye.
The drug was vonoprazan fumarate, a stomach acid blocker sold in the United States as Voquezna. She felt fine throughout. Her laboratory work stayed normal. The glow disappeared once the drug cleared her system and came back when dosing resumed, according to a case report by Lei Sheng and Xuening Li of the Department of Clinical Pharmacology at Zhongshan Hospital, Fudan University.
