George Alagiah has announced that he is taking a break from his presenting duties on BBC's News At Six after scans showed that his bowel cancer has spread further.
The BBC star, 66, was first diagnosed with stage 4 bowel cancer in 2014.
Amid his cancer battle, George announced that he was stepping back from work in October last year, but he then returned to BBC News At Six in April.
Sadly, George has now revealed that he will once again have to take a step back from his BBC duties to 'sort out the tough stuff'.
Announcing the news on social media, George's agent agent Mary Greenham wrote on his behalf: "A recent scan showed that my cancer has spread further so it's back to some tough stuff.
"I'm missing my colleagues. Working in the newsroom has been such an important part of keeping energised and motivated.
"I look forward to being back in that studio as soon as I can."
Last month, the newsreader revealed he had a 'tumour site' at the base of his back and has spent 18 months in 'extreme pain'.
"It is near my L5 lowest vertebra. I've spent a lot of the last 18 months in extreme pain. There have been times when even lying down makes it worse," he told The Sunday Telegraph.
Asked if the cancer had spread to his spine, George said: "I don't know if it is into my spine. It is very technical so you have to be careful.
"What I have is a tumour that is resting very close to the spine and, as far as doctors can make out, has eroded a bit of a vertebra.
"More importantly, it is sitting very close to the nerve and the aorta. Both of which are significant. That's the one we are watching."
Despite being in agony while working, George says his job still gives him a boost.
The newsreader, who returned to screens in April after a six-month break, previously said: “I’ve spent a lot of the last 18 months in extreme pain.
"There have been times when even lying down makes it worse.
“By the time I walk out of that newsroom at seven o’clock in the evening, having been there since the morning, I am absolutely knackered physically – but mentally I am rejuvenated.”
After his initial stage four diagnosis he had 17 rounds of chemotherapy but the cancer came back in 2017.
Sri Lanka-born George, whose BBC team won a Bafta in 2000 for its Kosovo coverage, spoke movingly about his fear of leaving behind his wife, Frances Robathan.
He told the Sunday Telegraph: “One of the things I want to do is hold hands with my wife until the end, and am I going to be able to do that?
“It haunts me.”
