
Once upon a time on General Hospital, the biggest rivalry in all of Port Charles was between the Cassadines and the Spencers. The deeply rooted bad blood between the two families led to the craziest of storylines.
We’ll admit, the feud was at its best when Helena (Constance Towers) was leading the Cassadines and Luke (Anthony Geary) was leading the Spencers. The cat-and-mouse game between these two was comical at times, and their constant need to one-up each other created chaos full of kidnappings, attempted murders, explosions, mind control surgeries, curses and in the case of Lulu, an offspring.