Antonio Conte will be hoping that his side can continue their recent good form as they travel to Old Trafford on Wednesday night for a tricky test under the lights.
It will be a crucial match, with United currently pushing for a place in the league's top four and Spurs hoping to keep pace with Arsenal and Manchester City in the title race,
However, Conte will have to make do without some of his key men, with both Dejan Kulusevski and Richarlison looking set to miss the match on Wednesday with injury.
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The latter suffered an injury against Everton at the weekend but looks set to be fit for the World Cup despite missing a crucial set of fixtures for the rest of this month.
Conte told official club media after the weekend's match that there would be a period on the sidelines for the former Everton forward, who went down in the 52nd minute against his old club, holding his left club.
"Richy has his injury, it's not a serious injury, but he needs a bit of time to recover. But, for sure, it's not a serious injury. He was really worried after the game against Everton." Conte said.
"Deki is another player who needs a bit of time to recover. The medical department are working in a strong way to give me the possibility to have an important player in my choice, but we have to wait. Lucas is available. He's working and starting to have good physical condition."
Here is the full list of players Conte has to choose from:
Goalkeeper: Hugo Lloris, Fraser Forster, Brandon Austin
Defence: Matt Doherty, Davinson Sanchez, Eric Dier, Cristian Romero, Ryan Sessegnon, Djed Spence, Japhet Tanganga, Ben Davies, Clement Lenglet, Ivan Perisic
Midfield: Oliver Skipp, Pierre Emile Hojbjerg, Pape Matar Sarr, Rodrigo Bentancur, Yves Bissouma, Harvey White
Attack: Harry Kane, Bryan Gil, Lucas Moura, Son Heung-min
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