Luke Shaw, Phil Jones and Jadon Sancho are among the Manchester United players who could miss their final game of the season at Crystal Palace.
Shaw's partner, Anouska, gave birth to their second child on Friday and the left-back is unlikely to participate in United's final training session before they travel to London.
Jones and Sancho withdrew from Friday's training session and Alejandro Garnacho has missed most of first-team training since his FA Youth Cup final heroics last week due to illness.