Fred is out of Manchester United's Premier League home game with Norwich through injury.
The midfielder was forced off midway through the first-half in the defeat at Everton last week and has not recovered in time for Saturday's game.
Luke Shaw could miss the rest of the season after undergoing surgery last week to have bolts removed from the double leg break he sustained against PSV Eindhoven in September 2015. Scott McTominay and Raphael Varane are also still out.
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Paul Pogba could start at Fred's expense and 18-year-old Tunisia international Hannibal Mejbri is vying for his home debut.
"Five players will still be missing for tomorrow, some of them probably also for the upcoming games," United interim manager Ralf Rangnick said. "Fred and Scott, Raphael Varane will still be missing out, Luke Shaw had his bolts removed from his leg and Edinson Cavani, those are the five that will still be missing.
"As it seems, [Shaw] will be out for at least another four or five weeks, I think for him it will be difficult for him to be available for the remaining seven games."
Although Erik ten Hag is effectively the United manager-elect, Rangnick was again reluctant to speak about the Ajax coach's merits to manage United.
Ten Hag is believed to have verbally agreed to take over at United but the club is yet to make an official announcement.
"I don't know if it's a done deal and my reply is the same as Erik ten Hag's, my focus is on the game against Norwich, prepare the team on a higher level for the game," Rangnick added.
"Again, it doesn't make sense (to speak about Ten Hag). We all know he's a good manager, he's done a good job at Ajax and former clubs but it doesn't make sense if I tell you what I think of another coach."
