Michael Keane starts for Everton as he replaces Yerry Mina in the starting line-up for Watford.
Mina was forced off after just 16 minutes at Leicester City on Sunday and Frank Lampard has since confirmed the defender is unlikely to be available again before the Blues face Arsenal on the final day of the season.
Everton will be hoping they have confirmed their Premier League status by then - and they could take a huge stride towards that goal with three points at Vicarage Road tonight.