Aaron Wan-Bissaka is absent from Manchester United's squad to play Leeds due to illness, while forward Jadon Sancho has also been deemed not fit enough to start the game after suffering from a bout of sickness himself earlier in the week.
United welcome historic rivals Leeds to Old Trafford on Wednesday night, but the side has been hit with an injury crisis, with Anthony Martial, Antony, Christian Eriksen, Donny van de Beek and Scott McTominay all currently sidelined with different concerns.
Casemiro is also unavailable for the match, as he was shown a straight red card against Crystal Palace at the weekend.
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Regarding the Reds' starting line up against Leeds, those six players being unavailable means Ten Hag's hand was forced to an extent and the key midfield absences have seen Marcel Sabitzer, Fred and Bruno Fernandes make the midfield three.
In the absence of Wan-Bissaka, Diogo Dalot has returned to the side, while Alejandro Garnacho has been given an opportunity to make his third start of the Premier League season, as Sancho was considered not fit enough to make the line up.
Ten Hag discussed his selection ahead of kick-off on Wednesday and when asked about Wan-Bissaka, he said: "illness."
The United boss also told MUTV: "After his [Dalot] return from the World Cup he struggled, but he also played some games, then he had a setback, but now he's ready. In the last couple of days, he was in full team training, so he's ready to start.
"He [Sabitzer] is experienced, he understands football, he understands the way we want to play, so let's give him the opportunity and I'm confident that we have a good midfield and good team today. This is also an opportunity [Garnacho].
"I've been really happy with him from the bench and I think we are doing this quite well this season, many players coming from the bench and Garnacho is probably the best example, he has such an impact, but he also wants to be a starter. He wants to play every minute and this is a good opportunity."
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