Erik ten Hag had decided to send on Fred and Anthony Martial before Tottenham scored in their draw with Manchester United.
Ten Hag replaced Christian Eriksen and goalscorer Jadon Sancho in the 61st minute - five minutes after Spurs wing-back Pedro Porro scored to make it 2-1.
Eriksen had excelled in midfield and Sancho enjoyed arguably his finest performance of the season before their removals. Ten Hag then sent on Wout Weghorst and Tyrell Malacia for Antony and Aaron Wan-Bissaka in the 71st minute.