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Gabriele Lignani, Associate Professor, Clinical & Experimental Epilepsy, UCL

Epilepsy: gene therapy technique targeting overactive brain cells shows promise in treating drug-resistant form of the condition

Epileptic seizures are caused by brain cells becoming overactive. MattLphotography/ Shutterstock

Something like 50 million people worldwide have epilepsy. While the majority of these people are able to use medications to manage and prevent their seizures, around one-third don’t respond well to these treatments. In such cases, the only option available to bring seizures under control is to remove the part of the brain where seizures arise. But this procedure is extremely risky.

Since epileptic seizures are caused by excessive activity of brain cells (neurons) in specific parts of the brain, being able to target these neurons and turn them off could very well prevent seizures from happening.

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