West Coast will fly home from hub life as winners after holding on for a thrilling two-point victory over St Kilda in the bottom-of-the-table clash at Trevor Barker Beach Oval.
No goals were kicked in the second half of Tuesday's match, with the Eagles pulling off a series of clutch tackles and spoils at the death to hold on for the 2.10 (22) to 2.8 (20) win.
It was a fitting end for the Eagles after more than three weeks in hub life.
Most of the squad was struck down by COVID-19 during that period and the hard slog on the road was made even tougher when they conceded a late goal in a three-point loss to Geelong on Friday.
But West Coast held firm against the Saints when it mattered most to secure their first win of the season.
"We spoke a lot about our last couple of minutes down in Geelong last week," Eagles coach Michael Prior said.
"We went through it, we learnt, and some of the things we went through we really put into play in that last two minutes.
"So really pleasing for the girls. To have a win it's outstanding."
St Kilda, who were playing their first game in 17 days, remain at bottom of the ladder with a 0-4 record.
"In no way did our preparation have any impact on tonight's performance," Saints coach Nick Dal Santo said.
"We got beaten by a team that were harder than us, that at times looked like they wanted it more.
"We simply didn't execute, particularly late in that last quarter."
The Saints have played all year without unvaccinated star Georgia Patrikios and Dal Santo doesn't expect her to return this season.
"Not as it currently stands," Dal Santo said.
"That's not my rules, that's the Government's rules and the AFL's rules."
Dana Hooker (20 disposals) and captain Emma Swanson (19 possessions) were influential for West Coast through the midfield, while Isabella Lewis was also important with 18 disposals.
Saints captain Hannah Priest battled hard for 23 disposals while forward Jessica Matin was lively but inaccurate with 1.3.
West Coast dominated the inside 50m count 14-1 in the opening term, but it was the Saints who came away with the only goal of the quarter via Matin.
The Eagles wasted their chances with the breeze, but they made amends in the second quarter with two goals.
St Kilda controlled play for large periods of the final term, but powerful forward Caitlin Greiser was twice denied a mark by the umpire despite appearing to hang on to the ball long enough.