Cubs’ Jeremiah Estrada, Brendon Little debut in 5-3 loss to Blue Jays

Cubs rookie Brendon Little throws to first base but is too late as the Blue Jays’ Matt Chapman gets an infield single in the sixth inning at Rogers Centre on Tuesday. (Getty)

TORONTO — Two Cubs relievers made their major-league debuts in the 5-3 loss to the Blue Jays on Tuesday with contrasting results. 

Before the game, the Cubs selected right-handed reliever Jeremiah Estrada as their second substitute player in Toronto.