Courteney Cox and Jennifer Ansiton first met on the set of Friends in 1994 and have been besties ever since.
It was Courteney - who turns 58 today - who picked up the pieces when Brad Pitt left Jennifer in 2005 and got with his Mr and Mrs Smith co-star Angelina Jolie, leaving Jen devastated.
And in a Vanity Fair interview from 2005, Jennifer, then 36, couldn't hide her heartbreak when the interviewer broached the subject of Brad's new romance with Angelina Jolie.