Chelsea navigated some brief scares at the Stade Pierre Mauroy to reach the last eight of the Champions League for the second season running under Thomas Tuchel.
The reigning European Champions responded to Burak Yilmaz's 38-minute penalty well to reclaim their two-goal lead, silence the boisterous home crowd and make the final period of the contest a stroll.
Christian Pulisic's neat finish on the stroke of half-time finished a sublime Jorginho pass before Cesar Azpilicueta's perfectly placed knee met a vicious Mason Mount cross for the game's winner. The victory makes it five in a row in all competitions, heading into Saturday's FA Cup Quarter-Final with Middlesbrough.