Charlie Sheen has experienced more very public ups and downs in his career than most in the entertainment industry, several of which he experienced during the run of Two and a Half Men. Created by Chuck Lorre, the sitcom launched Sheen into network TV stardom to the point of becoming the highest-paid actor on television. He was ultimately fired from the show in Season 8, and didn't hold back his feelings about Lorre during their feud before they'd eventually collaborate again in 2023. The target of that ire on one occasion? The Big Bang Theory.
