For the second consecutive year the 49ers may be facing the Arizona Cardinals in a game where the Cardinals don’t have their starting quarterback. Per ESPN’s Adam Schefter, both of the Cardinals’ top two QBs are dealing with injuries, and a start from their QB3 is on the table when they 49ers and Cardinals square off in Mexico City on Monday night.
Starting QB Kyler Murray is dealing with a hamstring injury that sidelined him for Arizona’s Week 10 win over the Rams. Backup QB Colt McCoy got the start, but had to exit because of a knee injury that could now sideline him for Monday’s showdown.
If McCoy is unable to play in Week 11, it would likely be former Penn State QB Trace McSorely under center for the Cardinals. He completed two of his four throws for 12 yards last week.
The 49ers would probably prefer not to see McCoy given what he did against them last season at Levi’s Stadium. He went 22-of-26 for 249 yards and a touchdown in Arizona’s 31-17 win.
It’s unlikely San Francisco will be sure of who’s starting for Arizona until much later in the week, though practice participation reports will tell some of the story. With the Monday game, the week gets pushed back so the first practice report will be released Thursday, and we could get an announcement from Cardinals head coach Kliff Kingsbury by Saturday.
