A two-decade study into cloning has revealed a fundamental flaw in the technology, demonstrating that repeated duplication leads to an accumulation of fatal genetic mutations. Researchers in Japan generated 1,206 cloned laboratory mice from a single female donor between 2005 and 2025.
Initially, no outward signs of trouble were observed across the first 25 generations. However, genetic mutations subsequently began to pile up, ultimately proving fatal. The 58th generation of clones, despite appearing physically normal, died within days of birth due to these accumulated genetic mutations.