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Saritha Krishna, Postdoctoral Fellow in Neurological Surgery, University of California, San Francisco

Brain tumors are cognitive parasites – how brain cancer hijacks neural circuits and causes cognitive decline

Gliomas can form connections with distant areas of the brain, exploiting them for their own spread and growth. Andriy Onufriyenko/Moment via Getty Images

Researchers have long known that brain tumors, specifically a type of tumor called a glioma, can affect a person’s cognitive and physical function. Patients with glioblastoma, the most fatal type of brain tumor in adults, experience an especially drastic decline in quality of life. Glioblastomas are thought to impair normal brain functions by compressing and causing healthy tissue to swell, or competing with them for blood supply.

What exactly causes cognitive decline in brain tumor patients is still unknown. In our recently published research, we found that tumors can not only remodel neural circuits, but that brain activity itself can fuel tumor growth.

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