Boris Johnson should sack Priti Patel over her department's handling of the Ukrainian refugee crisis, the leader of the Liberal Democrats has said.
In a speech at the party's spring conference on Sunday, Sir Ed Davey said the Home Secretary's response to the "humanitarian catastrophe " has been "utterly shameful".
But the Government said "the facts just do not support these accusations".
Ms Patel has been approached for comment.
The Lib Dem leader said: "She has answered desperation with delays. Crisis with confusion. Pain with paperwork.
"Friends, when we see parents and children, bombed out of their homes, journeying for days, in search of nothing more than a safe place to live, people across the UK have said loud and clear: we want to welcome them, with open arms.
"Just as we welcomed refugees of other conflicts in the past.
"The British people want to offer them a home - but Priti Patel has slammed the door in their face."
It came as the Government announced details of a new scheme to help people fleeing the Russian invasion.
Levelling Up Secretary Michael Gove said "tens of thousands" of refugees are potentially set to benefit from the new route, with the first expected to come the UK "in a week's time".
The Government has been criticised over the speed and scale of its efforts to bring people fleeing the war to the UK, with access previously limited to those with family members settled in this country.
Earlier this week, Conservative MPs joined the Opposition in launching a furious attack on the Home Office's response to the crisis.
On Tuesday, minister Kevin Foster confirmed 500 visas had been issued and the Ukraine family scheme had received more than 10,000 applications since its launch the previous Friday.
Mr Gove said on Sunday that "more than 3,000 visas" have now been issued, up from the 1,305 figure given by Home Office minister Baroness Williams of Trafford on Friday, correct as of Thursday morning.
Sir Ed alleged that Ms Patel has shown "incompetence, indifference and sheer inhumanity", which "does not befit our United Kingdom, with its proud history of providing sanctuary to those in need".
"Her inaction does not befit the British people, with all our compassion and generosity," he added.
"It couldn't be clearer that Priti Patel is not up to the job. The buck stops with the Prime Minister. So Boris Johnson must sack her, now."
A Government spokesperson said: "The Home Secretary this week announced changes that will make it simpler and quicker for those fleeing Putin's barbaric war to come to the UK, while balancing national security considerations given the real and varied threats we face.
"Since 2015, the UK has resettled more refugees through safe and legal routes than any other European country.
"Under the Home Secretary's tenure, the Home Office has welcomed the final of the 20,000 refugees from Syria, 20,000 Afghans and 97,000 Hongkongers.
"The facts just do not support these accusations."
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