Thousands of Border Force officials will walk out at the end of April in a long running dispute over pay, pensions and job security.
The airport and port workers are among more than 130,000 civil service workers who have voted to strike at the end of April.
With May bank holidays planned for May 1, it could cause possible disruption to Brits hoping to use the day off as an excuse for a long weekend abroad.
The industrial action will come after thousands of Border Force staff hit the picket line over the Christmas period.
On April 28 as many as 15,000 Border Force workers represented by PCS Union could walk out, potentially leading to chaos at travel hubs.
The last time that they did the government drafted in additional civil service and military resource to mitigate the strikes.
The PCS union, which represents hundreds of thousands of government workers, has been calling for a pay rise, better pensions and no cuts to redundancy terms.
Its members working for 186 different employers were balloted over strike action last week and opted to go ahead with it.
The announcement of a strike comes just a day after Unite security workers announced ten days of industrial action art Heathrow Airport from the end of this month.
“Our members are not backing down in this dispute,” said PCS general secretary Mark Serwotka.
“Ministers need to take notice that we’re escalating our action and they need to resolve the dispute by putting money on the table.
“We know our strikes have already caused serious disruption. The new strikes and another national day of action will pile the pressure on a government that refuses to listen.”
The Home Office has urged passengers to check the latest travel advice if they're leaving or returning to the country during the Border Force strike.
They should also be prepared for "longer wait times" and that the safety and secure of the border would not be compromised, a spokesperson for the government organisation said.
To add to the potential travel disruption, Passport Office workers are already planning to walk out for five weeks this spring.
More than 1,000 members of those workers represented by the PCS union in Durham, Glasgow, Liverpool, London, Newport, Peterborough and Southport are downing tools between 3 April and 5 May.
There are also strikes planned at 17 of the busiest airports in Spain as unionised workers at ground services and cargo handling company Swissport,
From 27 February to 13 April, they have called for a series of 24-hour walkouts every Monday, Tuesday and Thursday.
A spokesperson for the Home Office said: “The Home Office will work hard to manage the impact of this strike action to ensure they can still provide the vital service to the British public as you would expect ahead of the summer where we fully acknowledge that many people will want to get away and enjoy the summer with their family."
