Joe Biden has told American citizens to get out of Ukraine immediately and insisted that US troops will not be involved in any rescue missions if Russia invades.
The president gave his warning during an interview with NBC News as fears that Vladimir Putin will order troops into the country persist.
“American citizens should leave now. It’s not like we’re dealing with a terrorist organisation. We’re dealing with one of the largest armies in the world,” he said.
“It’s a very different situation and things could go crazy quickly.”
Anchor Lester Holt asked the president if there was a situation in which he would send in US troops to help Americans trying to flee the country.
“There’s not. That’s a world war when Americans and Russia start shooting at one another.”
And he added: “We’re in a very different world than we’ve ever been.”
US Secretary of State Antony Blinken on Friday said an invasion of Ukraine could come at any time, including during the Winter Olympics.
“Simply put, we continue to see very troubling signs of Russian escalation, including new forces arriving at the Ukrainian border,” Mr Blinken told a news conference in the Australian city of Melbourne.
“As we’ve said before, we’re in a window when an invasion could begin at any time, and to be clear, that includes during the Olympics.”
An invasion of Ukraine could see Russian tanks on the streets of Kiev within 48-hours, and up to 50,000 civilians killed or wounded within weeks, according to US intelligence agencies.
The State Department warned separately on Thursday that the US “will not be able to evacuate US citizens in the event of Russian military action anywhere in Ukraine”.
Mr Biden told Holt that if Vladimir Putin was “foolish enough to go in, he’s smart enough not to, in fact, do anything that would negatively impact on American citizens”.
Holt asked the president if he had ever told his Russian counterpart that directly.
“Yes,” Mr Biden replied.
“You’ve told him that, that Americans will be a line that they can’t cross?” asked Holt.
“I didn’t have to tell him that. I’ve spoken about that. He knows that,” said Mr Biden.