
Megabonk is a game about winning with whatever Weapons and Tomes the game offers you. While you can manipulate these choices with Banish, Refresh, and Skip, you'll rarely be able to pull off the perfect combo of upgrades that will give you an overpowered build.
If you fail to replicate the best builds in Megabonk in your run, it's useful to know which Weapons and Tomes make good combos regardless of other items. Since each Weapon has its own set of stats, you should try to match those that have the same stats so a single Item or Tome affects all your weapons at once instead of just one or two.