Get all your news in one place.
100’s of premium titles.
One app.
Start reading
Marie Claire
Marie Claire
Lifestyle
Samantha Holender

Benzoyl Peroxide vs. Salicylic Acid: Which Is Best for Your Acne?

Models with acne free skin after using benzoyl peroxide and salicylic acid.

So, you have acne. Welcome to the club. You and 50 million other Americans have to deal with various types of acne. Thankfully, the best benzoyl peroxide products and the best salicylic acid products can absorb excess oil, unclog pores, and prevent future breakouts.

Both acne-fighting ingredients are easily accessible (you can even find them at the drugstore), available in various concentrations, and come in cleanser, spot treatment, and pimple sticker delivery methods. Despite their similarities, the ingredients work slightly differently (benzoyl peroxide targets bacteria and inflammation, while salicylic acid focuses on exfoliation and pore cleanout). Knowing which is best suited to handle your current skin concern is quite literally the key to a clearer complexion.

To help you settle the benzoyl peroxide vs salicylic acid debate once and for all, we tapped board-certified dermatologists Marisa Garshick, M.D. FAAD, Christine Choi Kim, M.D. FAAD, and Pooja Rambhia, M.D. FAAD. Here, they’re sharing insight into the pros and cons of both ingredients, offering advice on how to incorporate them into your skincare routine for acne, and providing a realistic timeline for when to expect to see results.

Benzoyl Peroxide vs Salicylic Acid: What's the Difference?

"The biggest difference between the two ingredients is that benzoyl peroxide has antibacterial properties and is more helpful for inflammatory acne lesions like tender red papules and pustules," explains Dr. Kim. "However, salicylic acid has stronger comedolytic effects, so it's more effective at treating and preventing blackheads and whiteheads.”

The Benefits of Benzoyl Peroxide and Salicylic Acid

The main similarity between benzoyl peroxide and salicylic acid is their ability to fight acne. “Individuals who struggle with acne can benefit from adding either ingredient to their skincare routine,” says Dr. Garshick. “Both aid in preventing clogged pores by shedding dead skin cells and excess sebum,” notes Dr. Rambhia. Still, their individualized benefits are nuanced, and each is best suited for different types of acne.

  • Benzoyl Peroxide

Most commonly found in face washes for acne, benzoyl peroxide gets a dermatologist stamp of approval for its “ability to kill acne-causing bacteria, reduce inflammation, and prevent the formation of new pimples,” says Dr. Garshick. While it’s effective on comedonal acne, such as blackheads and whiteheads, it’s best known for fighting inflammatory acne, like cysts and pustules that tend to be red, swollen, and painful.

  • Salicylic Acid

While benzoyl peroxide is a keratolytic agent (aka an exfoliator that cleans out pores), salicylic acid is a stronger one—by a long shot. “It works by exfoliating the skin, shedding dead skin cells, and clearing up clogged pores,” notes Dr. Rambhia. It’s ideal for blackheads and whiteheads. “It also tends to be less irritating when compared to benzoyl peroxide, making it a safer choice for those with sensitive skin when used correctly.”

The Side Effects of Salicylic Acid and Benzoyl Peroxide

You don’t have to worry about any serious side effects with either ingredient. The American Academy of Dermatology recommends both. Plus, they are pregnancy-safe and are overwhelmingly well-tolerated.

  • Benzoyl Peroxide Side Effects

While benzoyl peroxide is generally safe to use, it can cause side effects like dryness, redness, and peeling, particularly when first introduced to the skin. “Those with other dermatologic conditions involving the area of concern, such as rosacea or eczema, may also experience irritation from benzoyl peroxide,” says Dr. Rambhia.

The ingredient also tends to leave its mark. “Benzoyl peroxide can also bleach dark clothing, bedding, and even your hair,” adds Dr. Kim. If you are going to use it before bed, consider laying a towel down or using a pillowcase you don’t care about.

  • Salicylic Acid Side Effects

Salicylic acid is more well tolerated than benzoyl peroxide, but it can still cause a bit of discomfort. “There can be dryness, irritation, redness, and stinging, especially in individuals with sensitive skin or when used in high concentrations,” says Dr. Garshick.

How to Know if Salicylic Acid or Benzoyl Peroxide Is Right for You

  • Type of Acne

“Those with inflammatory acne may find benzoyl peroxide particularly effective due to its antibacterial properties,” says Dr. Garshick, noting that inflammatory acne includes cysts and pustules. “Individuals with comedonal acne, such as blackheads and whiteheads, may benefit more from salicylic acid’s ability to penetrate and clear clogged pores.”

  • Skin Type

Salicylic acid may be the more tolerable option for sensitive skin. That said, benzoyl peroxide isn’t out of the question. You may want to consider a short contact treatment, such as a face wash. Those with oily skin may also prefer salicylic acid, as it can regulate long-term sebum production.

  • Lifestyle

Because benzoyl peroxide tends to stain bedding or clothing, it might not be the best choice if you want to preserve your sheets. Pimple patches, which are great for on-the-go treatments, also typically feature salicylic acid as the active ingredient.

The Best Benzoyl Peroxide Products

The Best Salicylic Acid Products

How to Incorporate Benzoyl Peroxide and Salicylic Acid Into Your Skincare Routine

How you add benzoyl peroxide or salicylic acid into your skincare is largely up to your tolerance and preference. “Benzoyl peroxide can be used in the morning or at night, as can salicylic acid.” says Dr. Garshick. That said, you’ll only want to use either ingredient once per day, and follow them up with a deeply hydrating moisturizer to prevent (or minimize) irritation, peeling, and flaking, as well as an SPF. “Both benzoyl peroxide and salicylic acid can make you more sensitive to the sun, so whenever incorporating these ingredients, it is important to remember sunscreen,” she adds.

If you have retinol in your routine, Dr. Rambhia recommends using benzoyl peroxide or salicylic acid exclusively in the morning.

Can I Use Benzoyl Peroxide and Salicylic Acid Together?

It depends. Some people with oily, thicker skin might be able to tolerate using one ingredient in the morning and one at night. But by and large double dipping in these acne-fighting ingredients will lead to “excessive dryness and irritation,” explains Dr. Garshick.

What Concentration of Benzoyl Peroxide and Salicylic Acid Is Best?

  • Benzoyl Peroxide Concentration

"In studies, benzoyl peroxide is equally effective at concentrations of 2.5 percent, five percent, and ten percent, but its irritation profile increases with higher concentrations,” says Dr. Kim. That in mind, it’s often recommended to start with five percent for your face. A 10 percent concentration should be well tolerated if you're treating body acne.

  • Salicylic Acid Concentration

Salicylic acid comes in concentrations ranging from 0.5 percent to two percent for over-the-counter topical use. “For those with mild to moderate acne, including blackheads and whiteheads, two percent tends to provide more effective exfoliation and unclogging of pores,” says Dr. Rambhia.

Meet the Dermatologists

Sign up to read this article
Read news from 100’s of titles, curated specifically for you.
Already a member? Sign in here
Related Stories
Top stories on inkl right now
One subscription that gives you access to news from hundreds of sites
Already a member? Sign in here
Our Picks
Fourteen days free
Download the app
One app. One membership.
100+ trusted global sources.