There are 17 places between Belgium and Wales in FIFA's World rankings but that didn't stop Wales holding Roberto Martinez's side to a 1-1 draw in Cardiff earlier this summer.
A late Brennan Johnson equaliser earned Wales their first Nations League point but they have a mountain to climb if they are to avoid dropping into UNL Group B.
The Dragons are a huge 7/1 with Betway to plunder maximum points from their trip to the King Baudouin Stadium while the hosts are 4/11 to return keep up the pressure on the Netherlands at the top of the section..
Belgium sit in second place, three points behind the Netherlands after a surprising 4-1 defeat to that rival on matchday one. They must now equal or better the Netherlands result on Thursday in order to remain in the hunt for top spot in Group D, and their prospects are boosted by the return of a host of big names, such as Kevin De Bruyne, Yannick Carrasco and Dedryck Boyata.
Page doesn't have such luxuries because Wales look set to be without experienced players Joe Allen, Ben Davies and Aaran Ramsay, while the Wales boss must decide whether to risk Gareth Bale who joined up with the squad late due to MLS actiion.
With just two group games remaining, Wales trail Poland, who they play in the final round, by three points, so are up against it after having to prioritise their rescheduled World Cup qualifier against Ukraine earlier this year.
Wales qualified for their first World Cup since 1958 earlier in the summer, and with the 2022 edition edging closer and closer, it is important that they build some momentum going into Qatar.
Belgium vs Wales prediction
Belgium will be looking to set up a 'winner takes all' clash with the Netherlands by taking all three points from this fixture and it's hard to see Wales repeating their Cardiff heroics with several key players missing. Wales have kept a clean sheet in just one of their last nine meaningful matches and they now face a Belgium side that have scored (remarkably) at least once in each of their last 54 matches.
However, Belgium don't keep clean sheets either - indeed they haven't kept one in their last eight competitive matches, two of which were against Wales. With that in mind, the obvious wager here is to back Belgium to win and both teams to score (yes), which is a 23/10 chance with Betway.
Belgium vs Wales prediction: Belgium to win and both teams to score (yes) - 23/10
Belgium vs Wales odds with Betway
- Belgium - 4/11
- Draw - 4/1
- Wales - 7/1
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