William Saliba and Oleksandr Zinchenko will reportedly miss Arsenal's meeting with Nottingham Forest on May 20 after being ruled out for the rest of the season through injury.
Steve Cooper's side host the Gunners in their final home game of the season as the Reds look to secure their top-flight status for another season. Forest are currently three points clear of the relegation zone with three games left.
The Gunners remain in a Premier League title race with Manchester City as they sit one point behind Pep Guardiola's side in the table although the Citizens have a game in hand.
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But Arsenal's title bid has taken a major blow after key defenders Saliba and Zinchenko were ruled out for the remainder of the campaign according to the Athletic.
They report that centre-back Saliba sustained a back issue in the Europa League defeat to Sporting Lisbon in March, while left-back Zinchenko picked up a calf problem during the win over Newcastle.
Arsenal are next in action at home to Brighton on Sunday whilst the Reds travel to Chelsea on Saturday before the two sides meet at the City Ground the following weekend.
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