Ant and Dec have been forced to pull out of work including tomorrow night's National Television Awards in London because they have both fallen unwell.
Stephen Mulhern will replace the pair and present a Britain's Got Talent special programme instead.
The Mirror reports that it's not clear if Ant McPartlin and Declan Donnelly will be fit enough to attend the NTAs on Thursday, during which they've consistently won the best TV presenter award for 20 years.
Their fans have been left devastated after the news was confirmed by ITV.
Ant and Dec were due to present two-hour special Britain's Got Talent: The Ultimate Magician, which brings together the world’s most memorable and greatest magicians from past series to compete and become the ultimate champion and win £50,000.
While Amanda Holden, Alesha Dixon and David Walliams will be returning, Simon Cowell won't as he has filming commitments in the US, TVZone has reported.
Simon will be replaced by world-famous magician Penn Jillette - one-half of the Penn & Teller team.
A BGT spokesperson told the online news outlet: "Ant and Dec are both unwell and have postponed all work commitments until they recover.
"Sadly, this means they were unable to film Britain’s Got Talent: The Ultimate Magician. Whilst we wish them a speedy recovery, we are thrilled to confirm that BGT’s favourite magician, Stephen Mulhern has stepped in."
The BGT special was filmed in front of a live studio audience on Tuesday and will see 10 acts compete for the prize.
Speaking about taking part in the show, Penn Jillette said: "“Being a guest judge on BGT is going to be the cushiest job ever. They’ve gone all around the world to find the most astounding magicians, and I get to sit and watch and be amazed. I cannot wait!”
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