When the Renaissance physician Andreas Vesalius wrote his magnum opus on human anatomy in 1543, he transformed the study of medicine and revolutionised the way scientists investigate the world.
A “mind-blowing” edition of his De Humani Corporis Fabrica Libri Septem, estimated to be worth up to £1m, is to be sold at auction for the first time since scholars discovered it was annotated by Vesalius himself.