The indie RPG Dread Delusion is one of my favorite recent games, and I'd chalk that up to ambition. I'm not just talking about doing an Elder Scrolls-style open world with a small team, but how it grapples with capital-B capital-I Big Ideas.
It's a setting where an "apostastic" inquisition persecutes belief and worship, a rebellion against the Lovecraftian gods who infest the world. This all happens on an archipelago of asteroids suspended between small "neuron stars" above a planet decimated by an ancient calamity.
