There are just some things that lend themselves to being great villains. There's snakes and Brits (aren't they the same thing, aha!) but there's also been the long-used theme of an artificial intelligence that gains sentience and then immediately realises that humans suck, and so tries to do away with us all.
We've had infamous cases like HAL-9000 from 2001: A Space Odyssey or AUTO from WALL-E in movies, or GLaDOS and SHODAN in videogames. There's certainly a lot of examples as to why humans probably shouldn't be racing to perfect the next thing that'll probably dislike us.
