Associated British Ports has been granted formal outline planning consent for Humber International Enterprise Park - a 4.25 million sq ft expansion beyond the huge Saltend site.
The industrial, manufacturing and logistics development spans 453 acres between Paull and Hedon, with almost half included in the freeport zone offering tax incentives for inward investors.
It is hoped up to 6,500 jobs could be created by companies moving in.
