The A189 Spine Road in Blyth has been closed for several hours following a serious collision on Sunday morning.
Three people were taken to hospital after the crash, with paramedics called to the scene at 3.45am. Two were taken to the Northumbria Specialist Emergency Care hospital in Cramlington and a third was transported to the Royal Victoria Infirmary (RVI) in Newcastle.
Emergency ambulance crews, the Great North Air Ambulance service and Hazardous Area Response Teams were all sent to the crash. Police remain on the scene as investigation work takes place into the crash.