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Madison Williams

49ers Will Be Without Another Running Back vs. Dolphins

49ers Dolphins Isaac Guerendo Christian McCaffrey Adam Schefter Elijah Mitchell Jordan Mason Miami San Francisco San Francisco 49ers

San Francisco 49ers running back Isaac Guerendo carries the ball. | Cary Edmondson-Imagn Images

The San Francisco 49ers' running back corps is expected to lose a fourth player for this weekend's matchup vs. the Miami Dolphins as Isaac Guerendo is dealing with a hamstring injury, ESPN's Adam Schefter reported.

The 49ers have had unfortunate luck regarding injuries this season. San Francisco has already lost Christian McCaffrey for the rest of the season with a PCL injury after he missed the first eight games with Achilles tendinitis. Jordan Mason will also miss the rest of the year with a high ankle sprain he suffered on Dec. 1. Elijah Mitchell has also missed the entire 2024 season with a hamstring injury.

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