Zach Cregger's Resident Evil movie has been (unfairly) divisive for its creative deviations from Resident Evil canon, and for telling a Resident Evil story without fan-favorite characters like Leon S. Kennedy and Claire Redfield. Nevertheless, it's set to open huge later this month, and could potentially double the opening weekend box office takings of the biggest Resident Evil movie to date.
Early tracking (h/t IGN) has put Resident Evil's opening weekend figure at some $40-50 million in the US. Even at the lower end of predictions, that's far higher than any movie in the Milla Jovovich-starring series, the biggest of which, Resident Evil: Afterlife, opened to $26.6 million in 2010. The most recent Resident Evil movie, Welcome to Raccoon City, opened to just over $5 million in November 2021. Even factoring in that more faithful adaptation's pandemic-era handicap, this is a big improvement.