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The Conversation
Daniel Kelly, Senior Lecturer in Biochemistry, Sheffield Hallam University

Younger men are turning to testosterone therapy in hopes of boosting mood and muscles – but there are risks of harm

The phenomenon of younger men turning to testosterone replacement therapy (TRT) to boost their “T levels” has been in the spotlight recently thanks to media reports and social media influencers.

Testosterone is a hormone critical to male health, influencing muscle mass, mood, cognition, libido and energy levels. Artificially raising testosterone levels through supplementation when levels dip seems logical. But is it?

Clearly, a large amount of research points towards beneficial effects of TRT for men with deficiency, including increased muscle mass and reduced fat mass, improved sexual desire and performance and better overall quality of life. But these findings come mostly from research in older men, leaving important questions unanswered about the effects of TRT in younger men. (It should be noted that TRT is not the same as anabolic steroids, which are drugs used purely to increase muscle mass.)

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