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Marie Claire
Marie Claire
Lifestyle
Nessa Humayun

You Can Now Get Polynucleotides Injected Into Your Lips—Here’s How the Results Compare to Filler

Lips.

Polynucleotides became the unofficial face of the regenerative aesthetics market last year, and their popularity shows no sign of slowing down. They were one of the most performed and most-searched for tweakments in 2025, and that number comprises myself: I have long waxed lyrical about my love of the "salmon sperm" tweakment.

They're an excellent alternative for those who may not want to opt for more invasive treatments like Botox or filler, and the results are fantastic: they boost collagen and elastin production, reduce inflammation and increase hydration, all for rejuvenated texture, tone and firmness.

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