The staging of a Fifa World Cup partway through the domestic seasons of many major leagues was always likely to be a problematic one for many reasons - not the least of which is the propensity for players missing out due to injuries.
While a handful suffering tournament absences is nothing new, the issue is exacerbated this time around because club matches will be continuing right up until a week before Qatar 2022 gets underway, with more matches crammed in and less recovery time for players beforehand too.
Unfortunately, a host of names are already confirmed as being out - while more are being added to the list of those racing against time to rediscover fitness with each passing round of fixtures.
That includes at least two players who could make Gareth Southgate’s England squad, with Chelsea’s Ben Chilwell the latest to be dealt a fitness blow.
Here’s a run-down of the players definitely out, and a regularly updated list of those who are facing an uphill battle to make it back in time.
Definitely out of Qatar 2022
Paul Pogba: The midfielder was at the heart of France’s World Cup win four years ago in Russia but will miss out with a long-standing knee injury.
N’Golo Kante: Formed the core of the France side of 2018 alongside Pogba but has undergone surgery on a hamstring injury and will not be in Qatar.
Presnel Kimpembe: The PSG defender is out of the World Cup, with France calling up Axel Disasi in his place. Kimpembe said: “My health comes first and the latest tests have shown that I will not be able to ensure a 200% performance and I do not want to destabilize the group.”
Christopher Nkunku: The Leipzig star jarred his knee in a challenge in training with Eduardo Camavinga and will miss the tournament.
Diogo Jota: The Liverpool forward has become a key performer for Portugal, but a serious calf injury sustained against Man City means he faces months on the sidelines.
Pedro Neto: Similarly, fellow Portuguese forward Neto will miss the tournament after sustaining ankle ligament damage playing for Wolves against West Ham.
Gini Wijnaldum: A broken leg suffered just days after his Roma debut means the Netherlands attacking midfielder will not return to action until early in the new year, depriving him of both the World Cup and winning a place at his new club.
Paulo Dybala: The Argentina forward has miraculously made it in time to be called up by Argentina after extensive physiotherapy and other treatment since tearing a thigh muscle while taking a penalty for his club, Roma.
Guilherme Arana: Brazil’s Olympic gold medal-winning left-back from last year in Tokyo was in line to start in Qatar, but a serious knee injury requires ligament reconstruction as well as surgery on his cartilage and medial meniscus - he’s out for the long haul.
Mike Maignan: The AC Milan goalkeeper would have been France’s No2, behind Hugo Lloris, but a calf injury is expected to sideline him until the new year.
Jesus Corona: There was no miracle and the Mexico winger is out after suffering an ACL injury over the summer. He wasn’t expected back in training with Sevilla until December and Gerardo Martino has now confirmed he won’t be called up.
Jakub Moder: The Brighton and Poland midfielder is out due to a long-term knee injury sustained just days after his nation confirmed their place in Qatar.
Miles Robinson: Centre-back for USA and Atlanta United, the 25-year-old tore his Achilles in May and is yet to return to action.
Chris Richards: Double defensive blow for USA as the Crystal Palace centre-back conceded he would not recover in time to be named in the squad on Wednesday.
Timo Werner: Germany’s forward came off in Leipzig’s final Champions League group game with an ankle injury and, despite initial hopes it wasn’t serious, examinations have revealed ligament damage and he’s out for the rest of 2022.
Ben Chilwell: The England full-back has battled through injury over the past 12 months in order to get himself fit for both club and country, but he has been ruled out with a hamstring tear suffered in the Champions Legue against Dinamo Zagreb.
Maxime Crepeau: Canada’s second-choice goalkeeper is out after fracturing his leg making a challenge - which he was sent-off for - in the MLS Cup final just two weeks before the World Cup.
Yuta Nakayama: The Huddersfield Town defender had been named in Japan’s 26-man squad before heartbreakingly suffering an Achilles tendon injury against Sunderland a couple of days later that ruled him out of the World Cup. He was replaced by 23-year-old Shonan Bellmare striker Shuto Machino.
Reece James: The Chelsea and England wing-back sustained a knee injury playing in the Champions League and has been in Dubai undergoing rehab, but confirmed on Wednesday he was “devastated” to announce he would miss out.
Mikel Oyarzabal: Spain’s winger tore his ACL in March and although he’s now back in training with Real Sociedad, he has failed to make their matchday squad for the final game in Spain before the national team’s announcement.
Giovani Lo Celso: The Argentina midfielder has been a regular through qualifying under Lionel Scaloni but he has failed to recover from a hamstring injury, report local media.
Sadio Mane: The Bayern Munich forward went off with a knee injury just two weeks before Senegal started their World Cup campaign. Called up to the squad, he was later ruled out following surgery.
Facing a race against time
Raphael Varane: The French centre-back injured his hamstring in Manchester United’s 1-1 draw at Chelsea last month and has posted pictures from France’s famous Clairefontaine training base as he tries to recuperate in time for Qatar.
Kyle Walker: The Manchester City and England defender, who has been so key to Gareth Southgate’s success in recent tournaments, is still recovering from groin surgery but believes he can return in time for the tournament.
Marco Reus: An injury suffered in mid-September was not initially thought to be too severe, but the Germany playmaker has suffered a setback. He has yet to return to action.
Raul Jimenez: The Wolves and Mexico striker is rushing to get himself fit for the tournament having barely played this season due to a groin injury.
Thomas Meunier: The Dortmund defender has been missing with a fractured cheekbone which required surgery, but he is hopeful of recovering to make Belgium’s World Cup squad.
Florian Wirtz: The Leverkusen forward has been out with an ACL injury and appears unlikely to recover enough to feature in Germany manager Hansi Flick’s final plans, despite being included in the preliminary 55-man squad.
Ronald Araujo: Having become a key Barcelona and Uruguay defender over the last 18 months, there’s still a fleeting hope that he returns from thigh surgery in time for the tournament but the original timeline put his return for December in a best-case scenario.
Atiba Hutchinson: Canada’s long-serving captain will be desperate to find fitness in time to make the squad after suffering a pre-season bone fluid issue. He’s yet to play for Besiktas this term.
Takehiro Tomiyasu: The Japan defender was forced off during Arsenal’s final Europa League group game on 3 November, with club coach Mikel Arteta looking to prevent the 23-year-old from suffering a more severe injury than the muscular one with which Tomiyasu is dealing.
Alphonso Davies: Canada’s star player pulled up with what appeared to be a hamstring injury playing for Bayern Munich, only two weeks before the start of the tournament.
Recovered and available
Son Heung-min: The Spurs and South Korea forward underwent surgery on a facial fracture sustained at Marseille in the Champions League. He required lengthy treatment on the pitch before being substituted, but has now confirmed that he will be fit and available to feature in Qatar.
Gareth Bale: The Wales captain had been lacking match minutes for sure, but a goalscoring appearance in the MLS Cup final showed he’s ready for action and he’s a certainty to be named on Wednesday night.
Richarlison: The Spurs forward picked up a calf injury against his former side Everton last month but was named in the Brazil squad this week despite not having yet returned for his club.
Kalvin Phillips: One of the mainstays of England’s run to the Euro 2020 final, The Manchester City midfielder had been out with a dislocated shoulder, but returned to action in the Carabao Cup on 9 November.