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USA Today Sports Media Group
USA Today Sports Media Group
Sport
Kyle Madson

Will Isaac Guerendo play this week? Injury updates for 49ers RB

The San Francisco 49ers can’t catch a break in their offensive backfield.

It started in training camp when running back Christian McCaffrey was shut down with what turned out to be Achilles tendinitis. RB Elijah Mitchell was also placed on season-ending IR in August with a hamstring issue.

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

Guerendo hurt his foot in Week 14, but played in Week 15 where he sustained a hamstring injury.

Isaac Guerendo injury update

Guerendo has been ruled out for Week 16 against the Miami Dolphins. He dealt with a hamstring injury in training camp that cost him most of camp and the first two preseason games. Head coach Kyle Shanahan indicated early in the week that Guerendo was a longshot to play. After not practicing all week he was listed as ‘out’ on the official injury report.

How long will Isaac Guerendo be out?

It’s unclear how long Guerendo’s absence will be. He showed promise in the reps he get as the 49ers’ primary RB, but the coaching staff will likely want to see more in-game opportunities for him in his rookie season. That doesn’t mean they’ll rush him into action, though. With three games left and nothing on the line there’s no real reason to risk a longer-term injury that may impact him into 2025.

49ers RB depth chart

Shanahan on Friday said veteran RB Patrick Taylor would ‘most likely’ get the starting role in Miami. Behind him on the active roster is Israel Abanikanda. Ke’Shawn Vaughn is on the practice squad and could be either elevated or promoted Saturday. If Vaughn is promoted to the active roster it would come with a corresponding move to clear a roster spot.

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