Ralf Rangnick picked Nemanja Matic to start ahead of Paul Pogba in the Manchester United midfield at Everton because of his quality in possession of the ball.
The Serbian has come into the side for Pogba, who drops to the bench for the vital Goodison Park clash, with both sides in desperate need of the points for differing reasons.
That is one of six changes in total from the side that drew with Leicester City a week ago. Aaron Wan-Bissaka, Victor Lindelof, Alex Telles, Marcus Rashford and Cristiano Ronaldo also come in for Diogo Dalot, Raphael Varane, Luke Shaw, Scott McTominay and Anthony Elanga.