Luke Shaw is struggling with a foot injury that has sidelined him for two of Manchester United's last three games.
Shaw has not played since he was substituted at half-time in the 4-0 thrashing by Brentford on August 13 and he was absent from the matchday squads against Leicester and Real Sociedad.
The 27-year-old was in line to start against Sociedad but did not participate in United's open training session the day before the Europa League defeat.