Which hospitals are affected by the junior doctors' strike TODAY - see full list

Thousands of junior doctors across England are going on a four-day strike over pay today in the "longest period of industrial action ever seen in the NHS".

An estimated 350,000 appointments, including operations, will be cancelled as a result of the walkout by members of the British Medical Association (BMA).

Doctors are mounting picket lines outside hospitals from 7am until Saturday morning in the longest stoppage of the wave of unrest, which has seen nurses, ambulance crews and other health workers take action since last year.

Managers have said patient care is "on a knife edge" because of the strike, while NHS Confederation chief executive Matthew Taylor said the number of appointments cancelled, previously suggested to be 250,000, was likely to rise by another 100,000.

A child joins striking NHS junior doctors on the picket line outside Leicester Royal Infirmary (PA)

The strikes centre around a pay row between the BMA and Government, with the union claiming junior doctors in England have seen a 26% real-terms pay cut since 2008/09 because pay rises have been below inflation.

The union has asked for a full pay restoration that the Government said would amount to a 35% pay rise - which ministers have said is unaffordable.

BMA officials said the pay issue is making it harder to recruit and retain junior doctors, with members previously walking out for three days in March.

NHS England said staff will be asked to prioritise emergency and urgent care over some routine appointments and procedures to ensure safe care for those in life-threatening situations.

The health body said appointments and operations will only be cancelled "where unavoidable" and patients will be offered alternative dates as soon as possible.

Here is a full list of the hospital picket lines where junior doctors are striking across England.

NHS staff demonstrate outside Aintree University Hospital in Liverpool (Julian Hamilton/Daily Mirror)

London

• King George Hospital
• Queens Hospital

• St Annes

• Barnet

• Royal London

• Whipps Cross

• St Barts

• Newham

• Croydon

• Epsom

• Great Ormond Street

• Guys

• St Thomas's

• Hillingdon

• Homerton

• St Mary's

• Charing Cross Hospital

• Kings College

• Princess Royal, Bromley

• Kingston

• Lewisham

• QEH Woolwich

• Northwick Park

• Ealing Hospital

• Jane Atkinson Centre

• North Middlesex UH

• Maudsley

• Royal Free

• Royal Marsden

• St George's

• University College

Junior doctors stand at a picket line outside King's College Hospital (Getty Images)

East of England

• Addenbrooks

• Norfolk & Norwich

• Lister

• Luton and Dunstable Hospital

• Watford General Hospital

• Broomfield Hospital, Chelmsford

• Peterborough City Hospital

• Basildon University Hospital

• Colchester General Hospital

• Princess Alexandra Hospital

• Hinchingbrooke Hospital

• Fulbourn Hospital, Cambridge

• Ipswich Hospital

• Southend Hospital

• West Suffolk Hospital

• James Paget Hospital

• Bedford Hospital

• Queen Elizabeth Kings Lynn

• Royal Papworth Hospital

Striking NHS junior doctors on the picket line outside Leicester Royal Infirmary (PA)

South East

• St Peter's Chertsey

• Darenth Valley

• Queen Elizabeth Queen Mother

• William Harvey

• Kent & Canterbury

• Conquest

• Eastbourne

• Bexhill

• Maidstone

• Medway Maritime

• Queen Victoria, East Grinsted

• Royal Surrey County

• Farnham Road

• Mill View

• St Richards

• Royal Sussex County

• Worthing

• Princess Royal, Lewes

The BMA is holding a 96-hour walkout in a dispute over pay (PA)

South Central

• Stoke Mandeville
• Winchester
• Basingstoke & North Hants
• Isle of Wight
• Milton Keynes
• John Radcliffe
• Churchill
• Horton
• Royal Berks
• Portsmouth
• Southampton

South West

• Callington Road
• Dorset County
• Cheltenham
• Gloucs Royal
• North Bristol
• Royal Cornwall
• Barnstable
• Exeter
• Bath
• Salisbury
• Somerset
• Torbay & South Devon
• Plymouth
• Bristol RI

• Yeovil

Junior doctors striking outside the Royal Devon and Exeter Hospital (SWNS)

West Midlands

• Birmingham Women's
• Birmingham Children's
• George Elliot
• Harplands
• City Hospital
• Warwick
• Russells Hall
• Robert Jones & Agnes Hunt
• New Cross
• Princess Royal, Telford
• Shrewsbury
• QE Birmingham
• Heartlands
• Good Hope
• UH Coventry
• Royal Stoke
• Walsall Manor
• Worcs Royal
• Alexandra, Redditch
• Hereford County

East Midlands

• NUH QMC
• NUH City
• Sherwood
• Chesterfield Royal
• Northampton
• Kettering
• Glenfield
• Leicester Royal
• Queens, Burton
• Royal Derby
• Lincoln County

Junior doctors on the picket line outside Leicester Royal Infirmary (PA)

Yorkshire and Humber

• Barnsley
• Bradford
• Huddersfield
• Calderdale
• Doncaster
• Harrogate
• Hull
• Leeds GI
• Leeds St James
• Pinderfields
• Scunthorpe
• Grimsby
• Rotherham
• Sheffield Children's
• Netherthorpe House
• Northern General
• Royal Hallamshire
• York
• Scarborough

North West

• Alder Hey
• Blackpool
• Bolton
• Chesterfield Royal
• Carlisle
• Macclesfield
• Royal Blackburn
• Prestwich
• Preston
• Royal Liverpool
• Aintree
• Manchester Uni: Oxford Road
• Manchester Uni: Wythenshawe
• Manchester Uni: North Manchester General
• Manchester Uni: Trafford General
• Leighton
• Salford Royal
• Royal Oldham
• Fairfield General
• Southport
• Whiston
• Stepping Hill
• Tameside General
• Christie
• Warrington
• Arrowe Park
• Wigan
• Lancaster

Doctors are mounting picket lines outside hospitals from 7am until Saturday morning (PA)

North East

• Darlington Memorial
• UH North Durham
• QE Gateshead
• Freeman
• RVI
• UH North Tees
• Northumbria Specialist
• James Cook
• Sunderland Royal
• South Tyneside

Figures provided by the BMA for confirmed picket lines as of April 6 only. There may be others that not yet been confirmed.