Deputy Prime Minister Dominic Raab is facing off against Angela Rayner at Prime Minister’s Questions on Wednesday.
The deputy party leaders are going head-to-head in place of Boris Johnson and Sir Keir Starmer.
Mr Raab is likely to come under fire following nation rail strikes led by the RMT last week, with further industrial action likely after rail bosses and the union failed to reach an agreement.
Ms Rayner is also likely to raise what Labour call “Backlog Britain” – with delays at the Passport Office and Britons seeking GP and dentist appointments.