Dewi Lake is set to miss the start of the Six Nations, with Wales coach Warren Gatland having already outlined Ospreys team-mate Scott Baldwin as his replacement.
Lake was forced off with a knee injury during the Ospreys' dramatic Champions Cup victory over Leicester Tigers on Friday night. Having missed out on the autumn campaign through an injury suffered after the squad was named, this would be more bad luck for the 23-year-old.
With established squad member Ryan Elias struggling with an Achilles problem, Gatland would have to look elsewhere for replacement hooker - with Baldwin's fine form in the Ospreys' European victories and his familiarity with the returning Wales coach likely swaying Gatland's head.