Experienced Wales prop Wyn Jones is not being considered as tight-head cover ahead of the second Test against the Springboks on Saturday.
It means one of two vastly-inexperienced youngsters – Sam Wainwright or Harri O’Connor – will be in line for their debut against the world champions this weekend.
After suffering a serious concussion in the 32-29 defeat at Lofus Versfeld, Wales’ first choice tight-head Tomas Francis has been stood down from the second and third Tests. He would have faced a mandatory stand-down period of 12 days so was automatically ruled out of the potential series equaliser, but medics have opted to send Francis home.