At least eight people were killed and more than 40 injured when thousands of protesters stormed the US Consulate General in Karachi on March 1, 2026, in violent demonstrations triggered by Iran's official confirmation that Supreme Leader Ayatollah Ali Khamenei was killed in joint US-Israeli airstrikes two days earlier.

The assault on the heavily fortified diplomatic compound in Clifton began shortly after 2 p.m. local time when a large crowd, estimated at 15,000–20,000 by police, breached outer security barriers despite heavy deployment of Rangers and Sindh police. Demonstrators, many waving Iranian and Palestinian flags and chanting anti-American and anti-Israeli slogans, hurled petrol bombs, stones and fireworks at the perimeter wall while attempting to scale it.