Cyanoacrylate vein closure was designed around a simple promise. A surgeon threads a catheter into a leaky leg vein, deposits medical adhesive, and the vein seals shut. No heat, no tumescent anesthesia, no numbing injections along the length of the thigh. The glue stays where it is put, and the body fibroses around it.
A case report in the Journal of Vascular Surgery Cases, Innovations and Techniques describes what happened when a patient's body declined that arrangement. Instead of tolerating the polymer, the tissue mounted a severe foreign-body reaction, formed multiple fistulas, and expelled the adhesive. Healing followed only after the material was gone.
