The US Central Command said its forces targeted and likely killed a senior ISIS leader who it said was involved in "planning terror attacks in the Middle East and Europe" in the early hours of Monday.
The US Central Command forces said it conducted the unilateral helicopter raid in Northern Syria, resulting in the probable death of the ISIS leader. Two other armed individuals were killed, it said.
US troops and civilians were not wounded in the attack, nor were US helicopters damaged, the Central Command said.
On Sunday, suspected ISIS militants killed at least 36 truffle hunters and five shepherds in Syria, a monitor said.
Rami Abdel Rahman of the Britain-based Syrian Observatory for Human Rights told AFP the extremist group "killed 36 people on Sunday while they were collecting truffles in the desert east of (the central city) Hama".
He said 17 of the dead were pro-regime fighters.
The official Syrian news agency SANA reported the deaths of at least 26 people.