Iain Henderson will undergo surgery today and joins Garry Ringrose on the Six Nations sidelines ahead of Ireland's Grand Slam finale with England on Saturday - but Dan Sheehan, Rónan Kelleher and Caelan Doris all remain in camp.
Ringrose suffered a head injury with eight minutes remaining of the 22-7 victory over Scotland in Murrayfield yesterday and his championship is over as he recovers.
Robbie Henshaw, who came off the bench in Edinburgh to make his comeback after four months out, is expected to start in place of Ringrose as Ireland chase a fifth successive victory in this year's championship.
READ MORE: Garry Ringrose injury update following bruising win over Scotland
Henderson is to go under the knife having fractured his forearm in the first half of the bruising encounter and his championship campaign is also done, leaving Ireland without two experienced second row campaigners in the Ulster skipper and Tadhg Beirne.
Leinster's Ross Molony, who was in camp in last year's Six Nations and for the 2021 summer series, has been added to the squad, with Ryan Baird expected to come into the side as James Ryan's second row partner.
Hookers Sheehan and Rónan Kelleher both suffered shoulder injuries in the game and had to come off, which left flanker Josh van der Flier throwing into the lineout and Cian Healy coming on as hooker to prevent Ireland going down to 14 men and uncontested scrums.
Both remain in camp this week, so there must be some optimism that one or both can feature against the Red Rose. Ulster’s Tom Stewart has been brought in as cover.
Caelan Doris was the first casualty at Murrayfield and his hip complaint will also be managed in camp this week, so he has not been ruled out.
Meanwhile, England have lost centre Ollie Lawrence for the fixture.
Lawrence sustained a hamstring injury during the final quarter of Saturday’s 53-10 mauling by France - England's heaviest ever defeat at Twickenham.
Guy Porter has been drafted into a 36-man training squad as centre cover but Manu Tuilagi is also available having completed his suspension for dangerous play.
Ireland Squad Round 5 – 2023 Guinness Six Nations Championships
Bundee Aki (Connacht/Galwegians) 45 caps
Ryan Baird (Leinster/Dublin University) 10 caps
Ross Byrne (Leinster/UCD) 18 caps
Craig Casey (Munster/Shannon) 10 caps
Jack Conan (Leinster/Old Belvedere) 37 caps
Gavin Coombes (Munster/Young Munster) 2 caps
Jack Crowley (Munster/Cork Constitution) 3 caps
Ciaran Frawley (Leinster/UCD) *
Tadhg Furlong (Leinster/Clontarf) 64 caps
Caelan Doris (Leinster/St Mary’s College) 27 caps
Jamison Gibson Park (Leinster) 24 caps
Mack Hansen (Connacht/Corinthians) 13 caps
Cian Healy (Leinster/Clontarf) 122 caps
Robbie Henshaw (Leinster/Buccaneers) 61 caps
Rob Herring (Ulster/Ballynahinch) 33 caps
Hugo Keenan (Leinster/UCD) 29 caps
Ronan Kelleher (Leinster/Lansdowne) 21 caps
Dave Kilcoyne (Munster/UL Bohemians) 51 caps
Jordan Larmour (Leinster/St Marys College) 30 caps
James Lowe (Leinster) 19 caps
Stuart McCloskey (Ulster/ Bangor ) 12 caps
Ross Molony (Leinster/UCD) *
Conor Murray (Munster/Garryowen) 104 caps
Jimmy O’Brien (Leinster/Naas) 4 caps
Peter O’Mahony (Munster/Cork Constitution) 93 caps
Tom O’Toole (Ulster/Ballynahinch) 8 caps
Andrew Porter (Leinster/UCD) 52 caps
Cian Prendergast (Connacht/Corinthians) 1 cap
James Ryan (Leinster/UCD) 52 caps
Roman Salanoa (Munster/Shannon) *
Johnny Sexton (Leinster/St Mary’s College) 112 caps (c)
Dan Sheehan (Leinster/Lansdowne) 16 caps
Tom Stewart (Ulster/Ballynahinch) *
Jacob Stockdale (Ulster/ Lurgan ) 35 caps
Nick Timoney (Ulster/Banbridge) 3 caps
Kieran Treadwell (Ulster/ Ballymena ) 10 capsJosh van der Flier (Leinster/UCD) 49 caps
*denotes uncapped player
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