Twins who were given zero per cent chance of survival have amazed doctors - and should soon be allowed home with their proud mum.
Harley and Harry Crane were conceived via IVF and were born at 22 weeks and five days – more than a week before the abortion limit.
Babies born at 22 weeks are not classed as legally viable and medical intervention is sometimes not offered. But the tough siblings weren't going anywhere and have amazed doctors – who initially gave them a zero per cent chance of survival.
Mum Jade Crane, 39, has spent the past 13 weeks staying by her brave babies' sides in the newborn intensive care unit (NICU) at Queen's Medical Centre in Nottingham.
But the miracle pair are doing well and it is hoped they'll be home for their due date, in a few weeks time.
The former mental health nurse and addiction counsellor, who lives in Derby with her husband Steve, 52, said: "I'm so proud of my babies – they're little fighters. They're doing absolutely amazing. They're doing all the things that we were told they wouldn't do.
"The doctors were saying the babies wouldn't survive at this gestation. The babies were given a zero per cent chance of survival. It was only because I was at a teaching hospital and that the babies were born with signs of life that they chose to intervene medically.
"It's crazy how much has happened, I'm not due until February 24 and yet they've been alive for 12 weeks now. The doctors are amazed, they're really rooting for us now. There's not one surgeon in the hospital who hasn't heard about our twins."
Jade and Steve had quite the journey to finally have their twins after 11 years of treatments – including eight cycles of IVF and several implantations of frozen embryos as well.
They had been trying to fall pregnant naturally for three years and Jade had suffered an ectopic pregnancy before they decided to start IVF in 2010.
After three tragic miscarriages on IVF, Jade discovered that she had an overactive immune system whereby her body would reject the pregnancies.
The couple moved from a fertility clinic in Nottingham to one on Harley Street in London – believed to be one of the best in the world – where Jade was prescribed lots of different types of medication in order to combat her immune system problems.
She said: "We had a really long IVF journey. Steve and I have been together for 14 years, and 11 of those have been spent doing IVF.
"On our eighth cycle of IVF, we had two embryos transferred which both worked and we ended up with boy and girl twins!
"I couldn't let myself believe it, I was so fearful of a miscarriage or something going wrong. I literally didn't do anything during the pregnancy as a result. I was still in disbelief when we got to 20 weeks, and I hadn't even hit my third trimester when I went into labour, so we hadn't bought anything!"
Jade took herself to get checked at Queen's Medical Centre on October 26 after leaking fluid at home for several days at 22 weeks pregnant.
An internal examination revealed that Jade was experiencing a premature rupture of membranes, whereby the fetal membranes rupture before the onset of labour.
With Jade only being 22 weeks pregnant, her babies were not considered to be viable and the poor mum believed she would lose her twins. She added: "The doctor was so shocked, she told me she could see the membrane bulging, so the sac of water was basically showing. It was so scary. I knew I was 22 weeks, but I didn't know about the viability thing. They told me they were going to admit me, but that I was probably having a miscarriage.
"The doctor kept saying it was a miscarriage, but I said it couldn't be because I could feel the babies moving. I knew they were OK, but was being told they wouldn't survive at this gestation."
The abortion law in the UK states that women can terminate a pregnancy up to 24 weeks.
Doctors are not required to medically intervene with babies born prior to 24 weeks gestation as they are not considered to be viable.
Jade had chosen to go to Queen's Medical Centre for her baby scans due to the fact that they had a more extensive NICU than her local hospital in Derby, and she wanted a higher level of monitoring due to her fertility history.
Luckily for Jade, the facility is a teaching hospital and doctors intervene with babies born 23 weeks and later in an effort to learn more about premature births.
At the time of going into labour on October 26, 2021, Jade was still 30 hours away from the 23-week mark – but doctors chose to intervene after her babies showed signs of life when born.
Jade said: "I was 30 hours away from what they would class as viable. Labour happened really quickly. I was denied pain medication and monitoring during labour as I wasn't viable, which was awful, really.
"It was only because the babies were born with signs of life that they chose to intervene medically. They were alive, moving around, and they cried. Their little cries sounded like a tiny kitten.
"I remember saying that I couldn't hear Harley cry and one of the nurses said I wouldn't because she was far too early but then I heard this little cry.
"Harry did the same when he was born an hour later, still in his sac. In Japan, it is seen as being lucky if you have a baby born in their sac, so I held on to that luck!"
Little Harley and Harry were intubated and taken to the NICU where they remained on ventilators as doctors worked hard to save the premature babies.
The twins have lots of health problems as a result of their premature birth, including chronic lung disease, and have undergone many surgeries in their little lives to combat them.
Harley now has a stoma bag fitted and Harry recently received injections in his eyes to help prevent premature blindness.
Devastatingly, the twins were also diagnosed with a serious gastrointestinal problem called necrotizing enterocolitis. This can be fatal, and Jade was told to prepare to say goodbye.
Jade said: "We were told to get the family in and have a christening. I kept referring to the christening as 'the funeral'. It was just awful."
Thankfully, the twins have defied the odds and are now thriving in the NICU after their shock arrival 12 weeks ago.
Jade and Steve are now preparing to bring their babies home with the hope they'll be able to leave the hospital near the original due date – February 24.
Jade said: "After they were born, I was Googling twins who survive at 22 weeks and trying to find any that have to give me hope.
"I found a set of twins in America who had survived – they're four now. I've connected with their mum on Instagram and she guided me through the first few days of being in the unit and what to ask for.
"I'm really lucky that I went to Queen's instead of Derby. If I'd gone to Derby Hospital, I wouldn't have come home with any babies, and that's where the ambulance would have taken me because of the catchment area – its a postcode lottery.
"We are working towards the twins coming home on my due date. Harley has to have a stoma reversal before she comes home, so they have spoken about potentially taking Harry home first.
"As this hasn't happened really before, they've got no medical evidence. Usually they'd say what they did with other babies at the same age, but they don't have any 22 weekers to base it on because it just doesn't happen.
"They'll go down in medical history – I'm pretty sure they'll be having on of the wards named after them because everyone is just amazed by them!"
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