Cristian Romero and Micky van de Ven both start for Tottenham in their Premier League showdown with Manchester United.
Van de Ven was an unused substitute for the FA Cup win over Burnley last Friday and is fit enough to return at Old Trafford this afternoon.
Romero rejoined the group this week and is reunited with Van de Ven at the heart of the Spurs defence, in a major boost for Ange Postecoglou.
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New signing Radu Dragusin, in the squad after receiving a work permit in time, is on the bench.
New signing Timo Werner starts the left of the front three, where missing captain Heung-min Son - who is away at the Asian Cup with South Korea - would normally play.
There is no Dejan Kulusevski in the Spurs squad.
Ben Davies (hamstring) and Giovani Lo Celso are the latest Spurs players to succumb to muscle injuries and could be sidelined for around a month, while Dane Scarlett is also out with a hamstring problem.
Yves Bissouma and Pape Sarr are away at the Africa Cup of Nations, while James Maddison (ankle), Manor Solomon, Ivan Perisic and Alejo Veliz (all knee) are also sidelined.
Confirmed Tottenham XI: Vicario, Porro, Romero, Van de Ven, Udogie, Bentancur, Hojbjerg, Skipp, Johnson, Richarlison, Werner
Subs: Dragusin, Gil Salvatierra, Emerson, Forster, Austin, Alonso, Donley, Dorrington
Time and date: 4.30pm GMT on Sunday January 14, 2024
TV channel: Sky Sports